In the PROGRESS trial (2001), the combination of perindopril and indapamide resulted in a stroke risk reduction of 43% both in hypertensive and non-hypertensive patients.

What is Indapamide?

Indapamide is an oral antihypertensive/diuretic. Its molecule contains both a polar sulfamoyl chlorobenzamide moiety and a lipid- soluble methylindoline moiety. It differs chemically from the thiazides in that it does not possess the thiazide ring system and contains only one sulfonamide group. The chemical name of indapamide is 4-Chloro-N- (2-methyl-1- indolinyl) -3-Sulfamoylbenzamide, and its molecular weight is 365. 84. The compound is a weak acid, pKa= 8.8, and is soluble in aqueous solutions of strong bases. It is a white to yellow-white crystalline (tetragonal) powder.

Thanks to http://www.rxlist.com/cgi/generic/indap.htm for Indapamide chemistry

Combination anti-platelet therapy was studied in the ESPS 2 trial showing a relative risk reduction for stroke of 30% with Aspirin and Dipyridamole versus Aspirin alone.

I think there is a role of Statins as well regardless of cholesterol level (even low)