You know the indication for Streptokinase installation in patients with pleural effusion/ empyema.

 Here is our routine.

Once indicated,

Streptokinase 250,000 units mixed with Normal saline in 50 ml syringe (total volume 50 ml)

put into chest tube

Flush with 50 ml of Normal saline.

We do it 12 hoursly for 3 days

and then review

if the patient need ?surgical intervention or not