Nowadays, C-diff infection has been a big problem especially among elderly patients. Remitting and relapsing trend is also common. In the last stool sample CDT showed "Not detected", they might come back with watery diarrhoea after sometime. CDT positive again. You may know metronidazole is less effective. We use Vancomycin 125 QDS for a few days. If diarrhoea gettting worse, we usually increase the dose to 500 QDS with or without Rifampicin 300 mg BD.

We do Immunoglobin levels which show lower limits or low level in those patients. We have tried Immunoglobulin infusion on 3 patients in last 2 months. Positive result has been found. One consultant recommended VSL 3.

 Well, regarding Probitics, this BMJ article is interesting.

Conclusion Consumption of a probiotic drink containing L casei, L bulgaricus, and S thermophilus can reduce the incidence of antibiotic associated diarrhoea and C difficile associated diarrhoea. This has the potential to decrease morbidity, healthcare costs, and mortality if used routinely in patients aged over 50.

I think more extensive research projects are required for use of Probiotics. Maybe there have been many and I don't know yet.