Many consider that Proton pump inhibitors (PPIs) may interfere with calcium absorption through induction of hypochlorhydria but they also may reduce bone resorption through inhibition of osteoclastic vacuolar proton pumps.After doing the controlled trial on 13 556 hip fracture cases and 135 386 controls, conculstion is "Long-term PPI therapy, particularly at high doses, is associated with an increased risk of hip fracture." Full article @ http://jama.ama-assn.org/cgi/content/abstract/296/24/2947